In the long run, diets don't work. In this study that I've mentioned previously, any of four diets (Atkins, Ornish, Zone, or Weight Watchers) led to only a 5 or 6 lb weight loss over a year's time. Other studies show the same result when they extend the time horizon out to a year or more.
In contrast, you can look at studies where calories were intermittently restricted and you see much better results. By intermittently restricted, I mean that calories are cut fairly low on some days with normal eating on the rest of the days. In the book, "The Alternate Day Diet", the idea is to restrict calories one day and have unlimited eating the next (as the title implies). Others recommend different frequencies as to how often calories should be reduced.
It's important to distinguish between intermittent calorie restriction and intermittent fasting. If intermittent fasting turns into eating a full day's calories in one meal, then there may not be much benefit. For example, if you look at studies on Ramadan fasting where a person fasts until evening but then has a large meal, there often isn't much change in body composition.
I think some of the intermittent fasting studies show benefits only because they indirectly restrict calories on fasting days. If a study has alternate-day fasting, then obviously a person will have no calories on one day. Or if someone fasts until 6 pm, it may be hard to eat enough calories as would normally be consumed in a day's eating.
In "The Alternate Day Diet", the author makes the case that the real benefits come from a 36-hour period of low calories. That is, eating much less one day and then sleeping on it. The benefits aren't dependent on not eating food for some many hours per se, as in one study subjects sipped on a protein shake throughout the day. It's the 36-hour period of low calories that triggers weight loss, and also lessens oxidative stress and inflammation.
What I wonder is why this approach is not more widely known. If you continually restrict calories, your metabolism will slow and the lost weight will come back. If you restrict calories every other day (or every third day or twice a week), then you can lose weight but the metabolism will not adapt and slow down.
It has to be easier psychologically to restrict calories only part-time as well. A lot of times on diets, people too much pressure on themselves and then they break down. With intermittent calorie restriction, you only have to control calories on some days, not all. This seems like a much more livable approach over the long term.





Hi Matt,
Why does he say only 36-hour periods are effective? What about the study showing that markers of inflammation are reduced in Ramadan fasters?
I think the point he is making is that a 36-hour period is much more effective in turning on the SIRT1 gene, and getting the associated benefits.
Ramadan fasting might do it a little bit, and have small decreases in inflammation, etc., but a 36-hour period produces much larger benefits.
I’ve read that calorie restricted mice are generally fed once daily. When they do eat, they are very hungry, and run out of food. A good part of their day is spent foodless. There could be an argument that some portion of the benefit of calorie restriction is from fasting.
Intermittent fasting leads to faster healing. Every other day fed mice whose hearts were surgically damaged healed quicker. Of course, insulin speeds healing, and when intermittently fasted mice do eat, there’s a bit of an insulin spike. Calorie restriction leads to slower wound healing. I guess there’s probably a place for both.
One of Mattson’s studies showed that eating full calories once a day doesn’t reduce the markers of oxidation.
I’ve actually been doing this exact thing but on accident! & I have managed to lose weight. It does work-or at least for me because I restrict my calories for two days and then eat normal the third day and by the fourth day when I wake up I’m amazed that I actually weigh less. However, this after two months of doing it like this. =]
Matt
I’ve put up a review of johnson’s book:
http://conditioningresearch.blogspot.com/2008/07/alternate-day-diet.html
Chris,
Will do, I’ll check it out.
Great post thanks for sharing. I’ve written up an Eat Stop Eat Review which I’d like you to check out.
Let me know what you think.
Thanks,
Tom